Infectious Chikungunya Virus in the Saliva of Mice, Monkeys and Humans
Identifieur interne : 002C50 ( Main/Exploration ); précédent : 002C49; suivant : 002C51Infectious Chikungunya Virus in the Saliva of Mice, Monkeys and Humans
Auteurs : Joy Gardner [Australie] ; Penny A. Rudd [Australie] ; Natalie A. Prow [Australie] ; Essia Belarbi [France] ; Pierre Roques [France] ; Thibaut Larcher [France] ; Lionel Gresh [Nicaragua] ; Angel Balmaseda [Nicaragua] ; Eva Harris [États-Unis] ; Wayne A. Schroder [Australie] ; Andreas Suhrbier [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN viral (métabolisme), Adolescent, Animaux, Charge virale, Enfant, Facteur-3 de régulation d'interféron (déficit), Facteur-3 de régulation d'interféron (génétique), Facteur-7 de régulation d'interféron (déficit), Facteur-7 de régulation d'interféron (génétique), Femelle, Fièvre chikungunya (anatomopathologie), Fièvre chikungunya (transmission), Fièvre chikungunya (virologie), Haplorhini, Humains, Modèles animaux de maladie humaine, Muqueuse olfactive (anatomopathologie), Muqueuse olfactive (virologie), Mâle, Salive (virologie), Souris, Souris de lignée C57BL, Souris knockout, Virus du chikungunya (génétique), Virus du chikungunya (isolement et purification).
- MESH :
- anatomopathologie : Fièvre chikungunya, Muqueuse olfactive.
- déficit : Facteur-3 de régulation d'interféron, Facteur-7 de régulation d'interféron.
- génétique : Facteur-3 de régulation d'interféron, Facteur-7 de régulation d'interféron, Virus du chikungunya.
- isolement et purification : Virus du chikungunya.
- métabolisme : ARN viral.
- virologie : Fièvre chikungunya, Muqueuse olfactive, Salive.
- transmission : Adolescent, Animaux, Charge virale, Enfant, Femelle, Fièvre chikungunya, Haplorhini, Humains, Modèles animaux de maladie humaine, Mâle, Souris, Souris de lignée C57BL, Souris knockout.
English descriptors
- KwdEn :
- Adolescent, Animals, Chikungunya Fever (pathology), Chikungunya Fever (transmission), Chikungunya Fever (virology), Chikungunya virus (genetics), Chikungunya virus (isolation & purification), Child, Disease Models, Animal, Female, Haplorhini, Humans, Interferon Regulatory Factor-3 (deficiency), Interferon Regulatory Factor-3 (genetics), Interferon Regulatory Factor-7 (deficiency), Interferon Regulatory Factor-7 (genetics), Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Olfactory Mucosa (pathology), Olfactory Mucosa (virology), RNA, Viral (metabolism), Saliva (virology), Viral Load.
- MESH :
- chemical , deficiency : Interferon Regulatory Factor-3, Interferon Regulatory Factor-7.
- genetics : Chikungunya virus, Interferon Regulatory Factor-3, Interferon Regulatory Factor-7.
- isolation & purification : Chikungunya virus.
- chemical , metabolism : RNA, Viral.
- pathology : Chikungunya Fever, Olfactory Mucosa.
- transmission : Chikungunya Fever.
- virology : Chikungunya Fever, Olfactory Mucosa, Saliva.
- Adolescent, Animals, Child, Disease Models, Animal, Female, Haplorhini, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Viral Load.
Abstract
Chikungunya virus (CHIKV) is a reemerging, ordinarily mosquito-transmitted, alphavirus that occasionally produces hemorrhagic manifestations, such as nose bleed and bleeding gums, in human patients. Interferon response factor 3 and 7 deficient (IRF3/7-/-) mice, which are deficient for interferon α/β responses, reliably develop hemorrhagic manifestations after CHIKV infection. Here we show that infectious virus was present in the oral cavity of CHIKV infected IRF3/7-/- mice, likely due to hemorrhagic lesions in the olfactory epithelium that allow egress of infected blood into the nasal, and subsequently, oral cavities. In addition, IRF3/7-/- mice were more susceptible to infection with CHIKV via intranasal and oral routes, with IRF3/7-/- mice also able to transmit virus mouse-to-mouse without an arthropod vector. Cynomolgus macaques often show bleeding gums after CHIKV infection, and analysis of saliva from several infected monkeys also revealed the presence of viral RNA and infectious virus. Furthermore, saliva samples collected from several acute CHIKV patients with hemorrhagic manifestations were found to contain viral RNA and infectious virus. Oral fluids can therefore be infectious during acute CHIKV infections, likely due to hemorrhagic manifestations in the oral/nasal cavities.
Url:
DOI: 10.1371/journal.pone.0139481
PubMed: 26447467
PubMed Central: 4598147
Affiliations:
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Le document en format XML
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Prow</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Belarbi, Essia" sort="Belarbi, Essia" uniqKey="Belarbi E" first="Essia" last="Belarbi">Essia Belarbi</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CEA, iMETI, Division of Immuno-Virology, Université Paris Sud and Center for immunology of viral infections and autoimmune diseases Inserm, UMR 1184, Fontenay-aux-Roses, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA, iMETI, Division of Immuno-Virology, Université Paris Sud and Center for immunology of viral infections and autoimmune diseases Inserm, UMR 1184, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>CEA, iMETI, Division of Immuno-Virology, Université Paris Sud and Center for immunology of viral infections and autoimmune diseases Inserm, UMR 1184, Fontenay-aux-Roses, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CEA, iMETI, Division of Immuno-Virology, Université Paris Sud and Center for immunology of viral infections and autoimmune diseases Inserm, UMR 1184, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Institut National de Recherche Agronomique, Nantes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut National de Recherche Agronomique, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Gresh, Lionel" sort="Gresh, Lionel" uniqKey="Gresh L" first="Lionel" last="Gresh">Lionel Gresh</name><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Sustainable Sciences Institute, Managua, Nicaragua</addr-line></nlm:aff><country xml:lang="fr">Nicaragua</country><wicri:regionArea>Sustainable Sciences Institute, Managua</wicri:regionArea><wicri:noRegion>Managua</wicri:noRegion></affiliation></author><author><name sortKey="Balmaseda, Angel" sort="Balmaseda, Angel" uniqKey="Balmaseda A" first="Angel" last="Balmaseda">Angel Balmaseda</name><affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua, Nicaragua</addr-line></nlm:aff><country xml:lang="fr">Nicaragua</country><wicri:regionArea>Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua</wicri:regionArea><wicri:noRegion>Managua</wicri:noRegion></affiliation></author><author><name sortKey="Harris, Eva" sort="Harris, Eva" uniqKey="Harris E" first="Eva" last="Harris">Eva Harris</name><affiliation wicri:level="2"><nlm:aff id="aff007"><addr-line>Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Inflammation Biology Laboratory, QIMR Berghofer Medical Research Institute, and the Australian Infectious Diseases Research Centre, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Chikungunya Fever (pathology)</term><term>Chikungunya Fever (transmission)</term><term>Chikungunya Fever (virology)</term><term>Chikungunya virus (genetics)</term><term>Chikungunya virus (isolation & purification)</term><term>Child</term><term>Disease Models, Animal</term><term>Female</term><term>Haplorhini</term><term>Humans</term><term>Interferon Regulatory Factor-3 (deficiency)</term><term>Interferon Regulatory Factor-3 (genetics)</term><term>Interferon Regulatory Factor-7 (deficiency)</term><term>Interferon Regulatory Factor-7 (genetics)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Olfactory Mucosa (pathology)</term><term>Olfactory Mucosa (virology)</term><term>RNA, Viral (metabolism)</term><term>Saliva (virology)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (métabolisme)</term><term>Adolescent</term><term>Animaux</term><term>Charge virale</term><term>Enfant</term><term>Facteur-3 de régulation d'interféron (déficit)</term><term>Facteur-3 de régulation d'interféron (génétique)</term><term>Facteur-7 de régulation d'interféron (déficit)</term><term>Facteur-7 de régulation d'interféron (génétique)</term><term>Femelle</term><term>Fièvre chikungunya (anatomopathologie)</term><term>Fièvre chikungunya (transmission)</term><term>Fièvre chikungunya (virologie)</term><term>Haplorhini</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Muqueuse olfactive (anatomopathologie)</term><term>Muqueuse olfactive (virologie)</term><term>Mâle</term><term>Salive (virologie)</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term><term>Virus du chikungunya (génétique)</term><term>Virus du chikungunya (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Interferon Regulatory Factor-3</term><term>Interferon Regulatory Factor-7</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Fièvre chikungunya</term><term>Muqueuse olfactive</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Facteur-3 de régulation d'interféron</term><term>Facteur-7 de régulation d'interféron</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chikungunya virus</term><term>Interferon Regulatory Factor-3</term><term>Interferon Regulatory Factor-7</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Facteur-3 de régulation d'interféron</term><term>Facteur-7 de régulation d'interféron</term><term>Virus du chikungunya</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Chikungunya virus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Virus du chikungunya</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN viral</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Chikungunya Fever</term><term>Olfactory Mucosa</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Chikungunya Fever</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Fièvre chikungunya</term><term>Muqueuse olfactive</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Chikungunya Fever</term><term>Olfactory Mucosa</term><term>Saliva</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Animals</term><term>Child</term><term>Disease Models, Animal</term><term>Female</term><term>Haplorhini</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="fr"><term>Adolescent</term><term>Animaux</term><term>Charge virale</term><term>Enfant</term><term>Femelle</term><term>Fièvre chikungunya</term><term>Haplorhini</term><term>Humains</term><term>Modèles animaux de maladie humaine</term><term>Mâle</term><term>Souris</term><term>Souris de lignée C57BL</term><term>Souris knockout</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chikungunya virus (CHIKV) is a reemerging, ordinarily mosquito-transmitted, alphavirus that occasionally produces hemorrhagic manifestations, such as nose bleed and bleeding gums, in human patients. Interferon response factor 3 and 7 deficient (IRF3/7<sup>-/-</sup>) mice, which are deficient for interferon α/β responses, reliably develop hemorrhagic manifestations after CHIKV infection. Here we show that infectious virus was present in the oral cavity of CHIKV infected IRF3/7<sup>-/-</sup> mice, likely due to hemorrhagic lesions in the olfactory epithelium that allow egress of infected blood into the nasal, and subsequently, oral cavities. In addition, IRF3/7<sup>-/-</sup> mice were more susceptible to infection with CHIKV via intranasal and oral routes, with IRF3/7<sup>-/-</sup> mice also able to transmit virus mouse-to-mouse without an arthropod vector. Cynomolgus macaques often show bleeding gums after CHIKV infection, and analysis of saliva from several infected monkeys also revealed the presence of viral RNA and infectious virus. Furthermore, saliva samples collected from several acute CHIKV patients with hemorrhagic manifestations were found to contain viral RNA and infectious virus. Oral fluids can therefore be infectious during acute CHIKV infections, likely due to hemorrhagic manifestations in the oral/nasal cavities.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Weaver, Sc" uniqKey="Weaver S">SC Weaver</name></author><author><name sortKey="Lecuit, M" uniqKey="Lecuit M">M Lecuit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suhrbier, A" uniqKey="Suhrbier A">A Suhrbier</name></author><author><name sortKey="Jaffar Bandjee, Mc" uniqKey="Jaffar Bandjee M">MC Jaffar-Bandjee</name></author><author><name sortKey="Gasque, P" uniqKey="Gasque P">P Gasque</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horwood, Pf" uniqKey="Horwood P">PF Horwood</name></author><author><name sortKey="Reimer, Lj" uniqKey="Reimer L">LJ Reimer</name></author><author><name sortKey="Dagina, R" uniqKey="Dagina R">R Dagina</name></author><author><name sortKey="Susapu, 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Ramachandra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Danis, B" uniqKey="Danis B">B Danis</name></author><author><name sortKey="George, Tc" uniqKey="George T">TC George</name></author><author><name sortKey="Goriely, S" uniqKey="Goriely S">S Goriely</name></author><author><name sortKey="Dutta, B" uniqKey="Dutta B">B Dutta</name></author><author><name sortKey="Renneson, J" uniqKey="Renneson J">J Renneson</name></author><author><name sortKey="Gatto, L" uniqKey="Gatto L">L Gatto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, O" uniqKey="Levy O">O Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hardy, Ga" uniqKey="Hardy G">GA Hardy</name></author><author><name sortKey="Sieg, Sf" uniqKey="Sieg S">SF Sieg</name></author><author><name sortKey="Rodriguez, B" uniqKey="Rodriguez B">B Rodriguez</name></author><author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name></author><author><name sortKey="Asaad, R" uniqKey="Asaad R">R Asaad</name></author><author><name sortKey="Lederman, Mm" uniqKey="Lederman M">MM Lederman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sykes, A" uniqKey="Sykes A">A Sykes</name></author><author><name sortKey="Edwards, Mr" uniqKey="Edwards M">MR Edwards</name></author><author><name sortKey="Macintyre, J" uniqKey="Macintyre J">J Macintyre</name></author><author><name sortKey="Del Rosario, A" uniqKey="Del Rosario A">A del Rosario</name></author><author><name sortKey="Bakhsoliani, E" uniqKey="Bakhsoliani E">E Bakhsoliani</name></author><author><name sortKey="Trujillo Torralbo, Mb" uniqKey="Trujillo Torralbo M">MB Trujillo-Torralbo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumar, M" uniqKey="Kumar M">M Kumar</name></author><author><name sortKey="Roe, K" uniqKey="Roe K">K Roe</name></author><author><name sortKey="Nerurkar, Pv" uniqKey="Nerurkar P">PV Nerurkar</name></author><author><name sortKey="Namekar, M" uniqKey="Namekar M">M Namekar</name></author><author><name sortKey="Orillo, B" uniqKey="Orillo B">B Orillo</name></author><author><name sortKey="Verma, S" uniqKey="Verma S">S Verma</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Tomori, O" uniqKey="Tomori O">O Tomori</name></author><author><name sortKey="Monath, Tp" uniqKey="Monath T">TP Monath</name></author><author><name sortKey="O Connor, Eh" uniqKey="O Connor E">EH O'Connor</name></author><author><name sortKey="Lee, Vh" uniqKey="Lee V">VH Lee</name></author><author><name sortKey="Cropp, Cb" uniqKey="Cropp C">CB Cropp</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Nicaragua</li><li>États-Unis</li></country><region><li>Californie</li><li>Pays de la Loire</li></region><settlement><li>Nantes</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Gardner, Joy" sort="Gardner, Joy" uniqKey="Gardner J" first="Joy" last="Gardner">Joy Gardner</name></noRegion><name sortKey="Prow, Natalie A" sort="Prow, Natalie A" uniqKey="Prow N" first="Natalie A." last="Prow">Natalie A. Prow</name><name sortKey="Rudd, Penny A" sort="Rudd, Penny A" uniqKey="Rudd P" first="Penny A." last="Rudd">Penny A. Rudd</name><name sortKey="Schroder, Wayne A" sort="Schroder, Wayne A" uniqKey="Schroder W" first="Wayne A." last="Schroder">Wayne A. Schroder</name><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name></country><country name="France"><noRegion><name sortKey="Belarbi, Essia" sort="Belarbi, Essia" uniqKey="Belarbi E" first="Essia" last="Belarbi">Essia Belarbi</name></noRegion><name sortKey="Larcher, Thibaut" sort="Larcher, Thibaut" uniqKey="Larcher T" first="Thibaut" last="Larcher">Thibaut Larcher</name><name sortKey="Roques, Pierre" sort="Roques, Pierre" uniqKey="Roques P" first="Pierre" last="Roques">Pierre Roques</name></country><country name="Nicaragua"><noRegion><name sortKey="Gresh, Lionel" sort="Gresh, Lionel" uniqKey="Gresh L" first="Lionel" last="Gresh">Lionel Gresh</name></noRegion><name sortKey="Balmaseda, Angel" sort="Balmaseda, Angel" uniqKey="Balmaseda A" first="Angel" last="Balmaseda">Angel Balmaseda</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Harris, Eva" sort="Harris, Eva" uniqKey="Harris E" first="Eva" last="Harris">Eva Harris</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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